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The General Election 2019: December 12: Against the Conservative Sociology of Squalor

The Political Philosophy, That Says That the Most Vital Part of the Public Affairs Management System, the System of Economics, That Shapes the Market and Directs the Course of Existence of the Entire Range of Business, Trade, Commerce and Financial Endeavours of a Nation and Ultimately Shapes the Human Condition of a Nation Should Not Be in the Ownership of the Entire Nation and Its People as Their State and Government Belong to Them and the Political Economics, That Says That the Survival of the Fittest or Richest Is the Ultimate Aim of Society, in Which the Vast Majority of the Population Must Exist and Perish Away in Serving a Live-in-Life Sentence of Suffering, Agony and Hardship and Must Accept All the High-Cruelties, High-Barbarities and High-Tortures, That Capitalism Creates, Distributes and Enforces are Nothing But a Brutal, Cruel, Ruthless and Inhuman Dictate of a Monstrous Social Jingoistic Jungle, Where Neither Civic Nor Community Can Exist Nor Can There Humanity Exist as Humanity Naturale as Individuals, as Families, as Communities, as Agencies and Organisations and as a Civic Society: And When Such a Monstrous Social Jingoistic Jungle is Established in a Country It Becomes Worse Than a Jungle and It Becomes Every Citizen's Civic and Moral Duty and an Existential Necessity of Humanity to Do All in Their Democratic Power to Eliminate Such Jingoistic Jungle and Replace It with a Civic Society Where Community, People, Families, Individuals and All Humanity are as Real, as Connected and as Active, as Engaged and as Creative as the Human Physiology Is in All Humans of a Given Society

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The Entire Spectrum of Colours and All the Forms, Manners and Expressions of Light are Made Invisible in This White: Or, Rather, Mix All the Colours and You Have This White: Or, Arrange All the Colours and Find an Infinite Rainbow: Or Take the Colours and Light Away and There Resides the Darkness But As Such That in Its Invisible Sphere There Still Remains Another Infinite Rainbow at Various States, That We Can Not See With Our Eyes: Take That All Away and You Have the Utter, Absolute and Primeval Duantum Darkness Within Which Our Matter Universe is Constructed and Does Function: Unless, We Remember This Every Nano-Second of Our Existence We Loose Our Sense and Joy of Eternal Wonder, Awe and Astonishment of This Magnificent Universe, Which is Outside, True, But Which is Nano-Seismically Constructed in the Human Physiology and Psychology: The Study of Medicine Will Always Remain and Fall Short Until It Sees and Learns That It is Dealing with the Universe, When It Goes About Learning and Healing This Human Physiology and Psychology: Alphansum Sovereign Necessarius: Munayem Mayenin

 

New Immune Pathway Involved in Resistance to Parasite Worms Found in Undercooked Pork

 

 

 

|| Monday: April 29: 2019: Lancaster University News || ά. Scientists from Lancaster University have discovered that immune responses, originally found to prevent fungal infections, are, also, important in eliminating Trichinella Spiralis, a round worm and the causative agent of Trichinosis. People acquire Trichinellosis by consuming raw or undercooked meat, infected with the Trichinella parasite, particularly, wild game meat or pork.

Consumption of contaminated meat contains ‘nurse cells’ of the parasite. Once in the stomach these ‘nurse cells’ hatch, releasing infective larvae, which, then, bury themselves within the lining of the small intestine. Previously, immune responses to expel the parasite have been shown to rely on white blood cells, called, T-helper two cells, specialised for eliminating gastro-intestinal parasites. However, scientists at Lancaster discovered that following this T-helper two response, a second T-helper 17 response, previously, shown to be specialised for eliminating fungal infections and certain bacterial infections occurred.

In collaboration with Professors Mark Travis and Richard Grencis from the University of Manchester, they were able to identify how these T-helper 17 cells arose and that they were key in maintaining the intestinal muscle contractions needed to flush out the worms.

The findings have been published in the journal PLOS Pathogens and show that mice, lacking the ability to activate a key signalling molecule, important in producing T-helper 17 cells have a reduced ability to expel the parasite. Interestingly, they saw a delayed transit time in the small intestine hinting at alterations in muscle contraction.

In isolating the small intestine they demonstrated that a key molecule, produced from T-helper 17 cells, termed IL-17, could increase intestinal contraction and restoring levels of this IL-17 in their mice rescued their ability to expel the parasite.

“We were quite surprised by what we found during this study. Normally, these immune responses are thought of as acting quite distinctly, depending on what type of infection you, may, have. It’s well established that the T-helper two response is beneficial during gastro-intestinal worm infections, so, traditionally, any other response would be thought of as hindering worm expulsion. So, it was quite surprising to see that this late acting T-helper 17 response was actually beneficial to the mouse’s ability to resolve an infection and get rid of the worm.’’ said Dr John Worthington from the Department of Biomedical and Life Science in the Faculty of Health and Medicine led the research.

“Our study provides novel insights into how the immune system interacts with muscle contraction during intestinal inflammation. Although, the occurrence of this infection is very rare in the developed world, we hope, it will help us to design new treatments for the many millions of people, who suffer from intestinal parasitic infections worldwide and, may, even, inform other intestinal diseases, involving altered muscle function.”::::ω.

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Antibody Therapy Training Phagocytes to Destroy Tumours Now Tested on Patients
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

|| February 25: 2019: University of Turku News || ά. Developed by researchers at the University of Turku, an immune-therapeutic antibody therapy re-educates macrophages to activate passivated cytotoxic T-cells to kill cancer. The antibody therapy prevented the growth of tumours in several mouse models. The development of the therapy has now progressed to patient testing in a phase I:II clinical trial. One reason behind many unsuccessful cancer treatments is the cancers’ ability to hijack the immune system to support its own growth.

This is assisted by the so-called tumour-associated macrophages, that can be educated by cancer cells to dampen anti-tumour immune responses. Macrophages are phagocytes, that form the first line of defence towards invading pathogens and they have a crucial role in maintaining tissue homeostasis. Macrophages have a large repertoire of functions in immune activation and resolving inflammation. In collaboration with Professor Sirpa Jalkanen, of Immunology, Dr Maija Hollmén’s research group investigated the possibility to utilise tumour-associated macrophages to increase the immunological detection and killing of cancer cells.

Professor Jalkanen has studied the function of Clever-1 for a long time. Previously, her group has observed that Clever-1 controls leukocyte trafficking between tissues. Published in the journal Clinical Cancer Research, the Study found that blocking Clever-1 function on macrophages activated the immune system and was highly effective in inhibiting cancer progression.

By inhibiting Clever-1 functions, tumour-associated macrophages, that, normally, impair adaptive immune cell activation, such as, cancer cell killing by cytotoxic T-cells, were managed to be re-educated so that they had increased ability to present antigen and secrete pro-inflammatory cytokines, leading to increased activation of killer T-cells.

‘’These results are highly promising and present a completely new way to activate anti-cancer immunity.’’ says Doctoral Candidate Miro Viitala, who is the main Author of the Paper.

‘’Macrophages are an ideal drug development target as they express several molecules, that can be activated or impaired to transfer the macrophages into cells, that destroy cancer. In itself, this would increase beneficial inflammation in the tumour micro-environment, which would improve the efficiency of immune checkpoint inhibitors in those patients, whose response is weak due to lack of tumour-specific T-cell activation.’’

The antibody therapy, targeting Clever-1 worked in the studied tumour mouse models as efficiently as the PD-1 antibody therapy, that is in clinical use. The PD-1 antibody maintains the functionality of the killer T-cells. It is notable that the Clever-1 antibody therapy, targeting macrophages, also, increased the activity of the killer T-cells efficiently.

In certain mouse models of cancer, a combination of anti-Clever-1 and anti-PD-1 therapies prevented tumour growth and formation of metastases more effectively than either treatment alone.

‘’Every cancer is different. Therefore, it is important to explore the types of cancer where Clever-1 antibody therapy most effectively works on and to find biomarkers, that can be used to identify beforehand the patients, that will benefit the most from this kind of therapy.’’ Viitala says.

The Paper: Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T Cell Response Against Immunosuppressive Tumors: Miro Viitala, Reetta Virtakoivu, Sina Tadayon, Jenna Rannikko, Sirpa Jalkanen, Maija Hollmén: Published in the journal Clinical Cancer Research:  February 12: 2019

More information: Maija Hollmén:::ω.

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New Clinical Trial for Osteo-Arthritis Drug Gets Funding