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The Political Philosophy, That Says That the Most Vital Part of the Public Affairs Management System, the System of Economics, That Shapes the Market and Directs the Course of Existence of the Entire Range of Business, Trade, Commerce and Financial Endeavours of a Nation and Ultimately Shapes the Human Condition of a Nation Should Not Be in the Ownership of the Entire Nation and Its People as Their State and Government Belong to Them and the Political Economics, That Says That the Survival of the Fittest or Richest Is the Ultimate Aim of Society, in Which the Vast Majority of the Population Must Exist and Perish Away in Serving a Live-in-Life Sentence of Suffering, Agony and Hardship and Must Accept All the High-Cruelties, High-Barbarities and High-Tortures, That Capitalism Creates, Distributes and Enforces are Nothing But a Brutal, Cruel, Ruthless and Inhuman Dictate of a Monstrous Social Jingoistic Jungle, Where Neither Civic Nor Community Can Exist Nor Can There Humanity Exist as Humanity Naturale as Individuals, as Families, as Communities, as Agencies and Organisations and as a Civic Society: And When Such a Monstrous Social Jingoistic Jungle is Established in a Country It Becomes Worse Than a Jungle and It Becomes Every Citizen's Civic and Moral Duty and an Existential Necessity of Humanity to Do All in Their Democratic Power to Eliminate Such Jingoistic Jungle and Replace It with a Civic Society Where Community, People, Families, Individuals and All Humanity are as Real, as Connected and as Active, as Engaged and as Creative as the Human Physiology Is in All Humans of a Given Society: Sunday: July 28: 2019

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VII London Poetry Festival 2019: October 14-15
 

 

 

 

 

 

 

 

 

 

 

England Arkive The General Election 2017 June Eight
 

The National Institute for Health and Care Excellence Recommends Gene Therapy Treatment for Rare Inherited Retinal Dystrophy Eye Disorder

 

 

 

 

 

 

 

 

 

 

 

 

 

|| Monday: September 09: 2019 || ά. The National Institute for Health And Care Excellence:NICE is recommending a new gene therapy treatment for rare inherited eye disorder for use on the NHS. The draft, highly specialised technologies guidance, recommends Voretigene Neparvovec, also, called, Luxturna and made by Novartis Pharmaceuticals UK for people with vision loss, caused by Inherited Retinal Dystrophy from confirmed RPE65 gene mutations and who have enough viable retinal cells.

Voretigene Neparvovec is the first licensed gene therapy for vision loss caused by RPE65-meidated Inherited Retinal Dystrophy, which, are a group of eye diseases, caused by gene mutations. The gene therapy is injected by a surgeon into the retina, at the back of the eye. This results in the gradual degeneration of the light sensitive cells, photo-receptor cells, which are there.

It works by introducing a healthy copy of the defective RPE65 gene into the retinal cells, enabling people with the condition to produce functional RPE65 protein.

Mr Meindert Boysen, the Director of the Centre for Health Technology Evaluation at NICE, said, "This is a highly innovative treatment for a very distressing, inherited condition so we are pleased the company has worked with us and NHS England and Improvement to allow us to offer these families hope for the future.

The company's willingness to work with us early and constructively has allowed us to publish this guidance on a much faster timeline than normal which is good news for patients."

NICE evaluated Voretigene Neparvovec treatment took 20 weeks, instead of the averaging 38 weeks, within the Highly Specialised Technologies Programme

It is estimated that there are 86 patients eligible for Voretigene Neparvovec in England. The list price of the medicine is £613,410 per patient. This technology breached the Budget Impact Test, meaning that it would have cost the NHS more than £20 million in one of the first three years after being introduced.

However, the Company has a commercial arrangement with NHS England, making the treatment available to the NHS at a discount, the size, of which, is commercial in confidence. NICE expects to publish its final guidance next month, if, there are no appeals received from consultees, including, the company, healthcare professionals and patient:carer organisations of the draft recommendations.

The clinical trials show that, in short term, there is a prevention in deterioration of the disorder. However, there is currently no study for the long term but, the Committee is confident with the possibility of the outcome.

About the National Institute for Health and Care Excellence:NICE: NICE is the independent body, responsible for driving improvement in the health and social care system by allowing their products and resources to be available to these sectors, at a value for money to reduce inequalities and variation.

Readmore at nice.org.uk:::ω.

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The NHS England Calls for Applications From Female Healthcare Scientists to Apply for Its Leadership Development Scheme: Deadline May 10

 

 

 

|| March 13: 2019 || ά. Female healthcare scientists are invited to apply for the NHS England’s Leadership Development Scheme, aimed at mid-career healthcare scientists to develop leaders and increase their impact within their Trusts and beyond.

Led by the NHS England’s Chief Scientific Officer, the CSOWISE Healthcare Science Leadership Development Programme for the NHS England Scheme provides support for 32 healthcare scientists over 12 months through a leadership development programme, that includes mentoring, alongside, communication and leadership skills training.

In addition, successful applicants will have the opportunity to attend the Chief Scientific Officer conference and become WISE role models, helping to inspire the next generation to follow in their footsteps. The initiative was launched in partnership with WISE, the campaign for gender balance in science, technology and engineering, on International Women’s Day at the NHS England Chief Scientific Officer’s Annual Conference.

The 2019 scheme was formally announced by Professor Dame Sue Hill DBE, the Chief Scientific Officer for England, who, in support of the WISE campaign, has taken on the role of WISE Lead Ambassador, working in collaboration with a team of female leaders to encourage women and girls to value and pursue science, technology, engineering and maths.

Professor Dame Sue Hill DBE, the Chief Scientific Officer for England, said, “The initiative was a unique opportunity to inspire the next generation of female healthcare scientists to gain leadership, knowledge and experience. We are delighted to partner with WISE and launch this prestigious opportunity on International Woman’s Day for a fourth year.

Science and innovation play a crucial role in patient-centred service transformation and are vital to delivering new frontiers in areas, such as, Genomic Medicine and tackling anti-microbial resistance. Ensuring our healthcare system operates at the limits of science, this Programme recognises the significant contribution women make to technology and engineering, providing a global contribution to science in health and inspiring the next generation of scientists.”

Ms Helen Wollaston, the Chief Executive, WISE, highlighted the impressive impact from the previous fellowships and said, “The ripple effect of the WISE Fellowship has surpassed all expectations. We are delighted to be expanding the number of women involved in the programme. We look forward to using their stories to inspire more girls to see how choosing scientific subjects at school can lead to a career where they will make a real difference to people’s lives.”

Applications are open now. The deadline for applications is  May 10: noon. To find out more or apply visit the WISE website:::ω.

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Children’s Funding Cut by a Third Per Child Leaving Thousands at Risk of Falling Into Crisis: Over 1,000 Children’s Centres Have Closed Since 2004 While 760 Youth Centres Closed Since 2015

 

 

|| February 26: 2019 || ά. Shocking new figures from the UK’s leading children’s charities have today showed the funding available for children’s services has fallen by a third per child in England since 2010. The new analysis of official figures by Action for Children, Barnardo’s, NSPCC, the Children’s Society and the National Children’s Bureau, has identified ‘kids’ cuts hotspots’ across England, where local councils have faced the biggest real-term drop in this funding. Councils in London have suffered the largest cuts, with the top five worst-hit boroughs are all in the capital.

Westminster tops the list with funding slashed by more than half, 51%, followed by Tower Hamlets, 49%, Camden, 49%, Newham, 46% and Hackney, 46%. Yet, the problem stretches far beyond London. Areas, such as, Manchester, 45% drop, Nottingham, 43% and Birmingham, 43%, also, made it into the country’s top twenty ‘kids’ cuts hotspots’. Councils are facing a £03 billion funding gap for children’s services by 2025, with many services having already been stripped back or shut down. Over 1,000 children’s centres have closed since 2004, while 760 youth centres have shut since 2015. The charities are warning that thousands more children and young people could fall into crisis, if, these cuts continue.

Ms Julie Bentley, the Chief Executive of Action for Children, , said, “Children’s services are at breaking point and these alarming figures reveal the true scale of the devastating and dangerous funding cuts made year after year by successive governments. Every day at Action for Children we see that children’s services can be a lifeline for families, from helping mums suffering with post-natal depression or families struggling to put food on the table, to spotting children quietly living in fear of domestic abuse or neglect.

Thousands of families across the country rely on these services to step in and stop problems spiralling out of control. With the number of child protection cases and children being taken into care at their highest for a decade6, it’s unthinkable to continue forcing councils to make crippling cuts to services. Without urgent cash from central government, thousands more children at risk of neglect and abuse will slip through the cracks and into crisis.”

Despite cuts to funding for children’s services, many councils have sought to protect this area as best they can, with spending falling by less than the funding drop. Councils, may be, making up the difference by drawing on reserves or slashing spending on other areas but the charity alliance stressed neither approach is sustainable in the long term.

Mr Nick Roseveare, the Chief Executive of the Children’s Society, said, “Vulnerable children are continuing to pay the price as councils face a toxic cocktail of funding cuts and soaring demand for help. This shocking analysis lays bare the enormous scale of this funding challenge, which is making it near impossible for councils to offer vital early support to children and young people to prevent problems escalating.

Funding cuts are not only an inhumane economy, they are, also, a false one. The reductions in early help for children they lead to simply intensify the need for more costly interventions further down the road like taking children into care as they face growing risks, including, everything from substance misuse and mental health problems, to repeatedly going missing, and being sexually or criminally exploited.

The Government now faces a stark choice at the next Spending Review: either continue to leave councils short of the money they need to keep children safe, or address the funding gap and give some of our most vulnerable young people hope of a brighter future.”

Mr Javed Khan, the Chief Executive of Barnardo’s, said, “We have long warned about the ‘perfect storm’ in children’s social care. In every community children face growing challenges, from knife crime and gangs, to cyber-bullying and online grooming, to a crisis in mental health. It’s, even, harder for families struggling to make ends meet. And in many areas the services they once relied on just aren’t there anymore.

As a result, far too often families are reaching crisis point, with rising numbers of children being taken into local authority care. At Barnardo’s we see the impact of this failure to step in early. Children are suffering from trauma, affecting their education, health and happiness, with lifelong impact.

That’s why we’re calling on the Government to provide additional funds so that communities can support local children and parents in need of help.  But we, also, need to spend those resources wisely. That’s why Barnardo’s is taking a radical new approach, working with national and local partners and investing our own resource to co-design and deliver services that change children’s lives and the system around them, for the better.”

About Action for Children: Action for Children helps disadvantaged children across the UK through intervening early to stop neglect and abuse, fostering and adoption, supporting disabled children and by campaigning tirelessly to make life better for children and families. With over 550 services the charity improves the lives of more than 300,000 children, teenagers, parents and carers every year.

About the Children’s Society: The Children’s Society is a national charity, that works with the most vulnerable children and young people in Britain today. We listen. We support. We act. Because no child should feel alone.

About the National Children’s Bureau: The National Children’s Bureau is a leading children’s charity working to build a better childhood for every child. We champion children’s right to be safe, secure and supported, by using evidence and our expert knowledge to influence government policy, and help practitioners to do the best job possible, especially for the most vulnerable and disadvantaged children and young people.

About Barnardo’s:Last year 301,100 children, young people and families were supported by Barnardo’s through more than 1,000 services across the UK, such as young carers, care leavers, foster carers and adoptive parents, training and skills or parenting classes. We work to transform the lives of the UK’s most vulnerable children and every year we help thousands of families to build a better future. But we can not do it without you.

About the NSPCC: The NSPCC is the leading children’s charity fighting to end child abuse in the UK and Channel Islands. We help children who have been abused to rebuild their lives, protect those at risk, and find the best ways of preventing abuse from ever happening.:::ω.

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