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The General Election 2019: December 12: Against the Conservative Sociology of Squalor

The Political Philosophy, That Says That the Most Vital Part of the Public Affairs Management System, the System of Economics, That Shapes the Market and Directs the Course of Existence of the Entire Range of Business, Trade, Commerce and Financial Endeavours of a Nation and Ultimately Shapes the Human Condition of a Nation Should Not Be in the Ownership of the Entire Nation and Its People as Their State and Government Belong to Them and the Political Economics, That Says That the Survival of the Fittest or Richest Is the Ultimate Aim of Society, in Which the Vast Majority of the Population Must Exist and Perish Away in Serving a Live-in-Life Sentence of Suffering, Agony and Hardship and Must Accept All the High-Cruelties, High-Barbarities and High-Tortures, That Capitalism Creates, Distributes and Enforces are Nothing But a Brutal, Cruel, Ruthless and Inhuman Dictate of a Monstrous Social Jingoistic Jungle, Where Neither Civic Nor Community Can Exist Nor Can There Humanity Exist as Humanity Naturale as Individuals, as Families, as Communities, as Agencies and Organisations and as a Civic Society: And When Such a Monstrous Social Jingoistic Jungle is Established in a Country It Becomes Worse Than a Jungle and It Becomes Every Citizen's Civic and Moral Duty and an Existential Necessity of Humanity to Do All in Their Democratic Power to Eliminate Such Jingoistic Jungle and Replace It with a Civic Society Where Community, People, Families, Individuals and All Humanity are as Real, as Connected and as Active, as Engaged and as Creative as the Human Physiology Is in All Humans of a Given Society

''In simple terms, the sociology of squalor’s political economical basis was created from this fact that these two conservative-led governments have cut about £30 billion pounds from the working and non-working poor in the social security cuts, that’s 30x1000=£30,000 million pounds and, than, they added another £30 billions to that cut-away £30 billions and made a sum of £60 billions and gave that away to their rich masters as corporation tax cuts, that’s £60,000 million pounds! That meant that the working and non-working poor of this country had been made to pay for the financial crash while they had nothing to do with what caused the crash. That is the foundation on which they, they then, cut the size of the entire governments of all layers and all the central and local public, civic, community, family and youth services, national health service, the national social care, education, police, social services, higher education, judiciary, including, the legal aid and the cuts in number courts etc and much more have received cuts well beyond 50% and that’s a very conservative figure.''

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Beauroblubellogenics: The Science of Studying The Beautiful Blue Belle: The Blood Brain Barrier

The Humanion's Newest Section: Beauroblubellogenics: The Beautiful Blue Belle in poetic term and in scientific, Beauroblubellogenics: the neuro-science branch, that does nothing but studies the Blood Brain Barrier. Therefore, here, this is for Beauroblubellogenics for the Beautiful Blue Belle, the Blood Brain Barrier. Dear Reader, you, may not, have read these terms and heard of the ideas and concepts they represent, but they have been published and are part of the printed world. The printed world existed in 'imagination' and in living that imagination in learning and creating, which, then, became creative and scientific works, that, then, got into print, in which the ideas of the Beautiful Blue Belle was elaborated as part of the celebration of this astonishing 'mechanism' of the Blood Brain Barrier and, from there, arises Beauroblubellogenics. Here, The Humanion, presents Beauroblubellogenics, the science of studying the Blood Brain Barriers: We envision that the people, who are to take forward this discipline, are not only qualified Neurologists but are practising at the Most Senior Consultant Level and they are such minds, who have developed 'the equi-competence' in that same Most Senior Consultant-Level in all the major branches of Medicine so that not only have they the knowledge, expertise, insight, experience and study in them but, also, they have developed both a 'Nano-seismic' and 'Universal' views of Medicine, in between which views there exist myriad of other views, such as, atomic, anatomic, molecular, genetic, biochemical, neurological, genetics etc, as well as, a Philosophy of Medicine so that these minds are capable of seeing, looking and understanding 'The Mechanoprincipium-View' of the subject being studied. In other words, these are the minds, that can, only, be described as 'Living Encyclopaedic Minds': The Humanion: April 06: 2018

The Iliad and The Odyssey Through the Blood Brain Barrier to Devastate Glioblastoma: New Homeric Breakthrough Raises Hope for Future Therapies to Destroy Glioblastoma Tumour

|| Tuesday: May 14: 2019: University of Helsinki News: Päivi Lehtinen Writing || ά. Researchers from the University of Helsinki have discovered a chink in the armour of the tumour cells of Glioblastoma, a lethal brain cancer. Alongside the finding, the researchers, also, came up with a method for attacking this vulnerability. The results, gained in experiments conducted with cell cultures and a mouse model are promising.

Glioblastoma is the most prevalent and the most lethal type of brain tumour in adults, with no curative treatment currently available. Glioblastomas can not be surgically completely excised, as the tumour cells are adept at invading tissues and spreading around the brain. In addition, Glioblastoma cells are extremely resistant to existing drug therapies.

For a long time, researchers have been looking for weaknesses in Glioblastoma cells, which could be targeted with efficacious therapies. A research group, headed by Professor Pirjo Laakkonen at the University of Helsinki has already earlier found that the expression of a small fatty acid-binding protein:MDGI or FABP3 in Glioblastoma cells increases their ability to invade tissues and is linked with a poorer prognosis for the patient.

“Our new research revealed that Glioblastoma cells depend on the expression of a gene, which produces the MDGI protein. Inhibiting the function of this gene results in the death of the tumour cells.” Professor Laakkonen says.

The absence of MDGI caused instability in the membranes of lysosomes, cleaning organelles, found inside tumour cells, which, in turn, resulted in the leakage of acidic and proteolytic enzymes, contained in the lysosomes into the cytoplasm, initiating cell death.

Further investigations of the mechanism, leading to cell death showed that silencing MDGI caused changes in the phospholipid composition of the lysosomes in Glioblastoma cells. The transport of linoleic acid, a substance essential to humans, found in food, from outside to inside cells was disturbed, resulting in a significant change to the fatty acid composition of the lysosomal membrane. This change apparently increased the permeability of the membrane.

“Our research demonstrates that MDGI is a key factor, regulating and maintaining the structure of the lysosomal membrane. This is the first gene, found to regulate the stability of the membrane.” Professor Laakkonen says.

What makes this finding, particularly, interesting is that cell death, caused by leakage in the lysosomes of Glioblastoma cells can be activated by using drugs, that cross the Blood-Brain Barrier. In their studies, Professor Laakkonen's Group used an Antihistamine, known as, Clemastine.

In cell cultures, Clemastine resulted in lysosome-mediated cell death in Glioblastoma cells already at concentrations, which had no significant effect on healthy cells of different types. In mouse models, Clemastine was very effective in reducing the spread of brain tumours and improving the survival rate of the animals. In the case of the most invasive brain tumour model, the administration of Clemastine resulted in the disappearance of the entire tumour.

“Our findings demonstrate that Antihistamines and other drugs, that increase the permeability of the lysosomal membrane can be considered as an enhancing therapy for patients with Glioblastoma alongside established treatments.” Professor Laakkonen says.

The study was published in EMBO Molecular Medicine journal.

Contact: Professor Pirjo Laakkonen

Laboratory Animal Centre, Helsinki Institute of Life Science:HiLIFE and Faculty of Medicine: University of Helsinki: Tele: +358 50 4489100: email: pirjo.laakkonen at helsinki.fi

The Paper: Vulnerability of invasive glioma cells to lysosomal membrane instabilisation: Vadim Le Joncour, Pauliina Filppu, Maija Hyvönen, Pauliina S Turunen, Harri Sihto, Isabel Burghardt, Heikki Joensuu, Olli Tynninen, Juha Jääskeläinen, Michael Weller, Kaisa Lehti and Pirjo Laakkonen: Published in EMBO Molecular Medicine: 2019

Caption: Figure shows patient-derived glioblastoma in murine brain treated with saline:control:left panel: or clemastine:right panel:. Glioblastoma cells:red: are known to invade the brain:blue:. Invasive glioblastoma cells are impossible to remove by surgery and exhibit high resistance to chemotherapies. Clemastine-treatment destroyed the invasive cells leading to clear tumour:brain border: Image: Llaakkonen Lab: University of Helsinki:::ω.

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