V PRAT Conference 2018 in New York: From Mass Incarceration to Universal Education: Unlocking the System: October 26-27
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I Humanics Spring Festival 2019: April 06 in London

I Regine Humanics Annual Lecture 2019: Whither to Homo Sapiens: Delivered by Dr J Everet Green: April 06 in London

 

VII London Poetry Festival 2019: St Matthews at Elephant and Castle: Meadow Row: London SE1 6RG: October 14-15

 
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Beauroblubellogenics: The Science of Studying The Beautiful Blue Belle: The Blood Brain Barrier

The Humanion's Newest Section: Beauroblubellogenics: The Beautiful Blue Belle in poetic term and in scientific, Beauroblubellogenics: the neuro-science branch, that does nothing but studies the Blood Brain Barrier. Therefore, here, this is for Beauroblubellogenics for the Beautiful Blue Belle, the Blood Brain Barrier. Dear Reader, you, may not, have read these terms and heard of the ideas and concepts they represent, but they have been published and are part of the printed world. The printed world existed in 'imagination' and in living that imagination in learning and creating, which, then, became creative and scientific works, that, then, got into print, in which the ideas of the Beautiful Blue Belle was elaborated as part of the celebration of this astonishing 'mechanism' of the Blood Brain Barrier and, from there, arises Beauroblubellogenics. Here, The Humanion, presents Beauroblubellogenics, the science of studying the Blood Brain Barriers: We envision that the people, who are to take forward this discipline, are not only qualified Neurologists but are practising at the Most Senior Consultant Level and they are such minds, who have developed 'the equi-competence' in that same Most Senior Consultant-Level in all the major branches of Medicine so that not only have they the knowledge, expertise, insight, experience and study in them but, also, they have developed both a 'Nano-seismic' and 'Universal' views of Medicine, in between which views there exist myriad of other views, such as, atomic, anatomic, molecular, genetic, biochemical, neurological, genetics etc, as well as, a Philosophy of Medicine so that these minds are capable of seeing, looking and understanding 'The Mechanoprincipium-View' of the subject being studied. In other words, these are the minds, that can, only, be described as 'Living Encyclopaedic Minds': The Humanion: April 06: 2018

 
Pioneering Treatment to Be Given to Creutzfeldt-Jakob Disease Patient for the First Time

 

 

 

|| October 10: 2018: UCL News || ά. A patient with Creutzfeldt-Jakob Disease:CJD, is set to be given a pioneering treatment, which has been developed by researchers at the Medical Research Council:MRC Prion Unit at UCL. CJD is a rare but devastating disease, that causes brain damage and for which there is currently no treatment. It is always fatal and most patients sadly die within six weeks of diagnosis. Researchers at the MRC Prion Unit at UCL have developed an antibody, called PRN100, for treating CJD. Laboratory testing of the antibody has been encouraging but it has not yet been used in patients.

Doctors at University College London Hospitals:UCLH will give the antibody to a patient for the first time in the world after a judge in the Court of Protection confirmed that it is lawful and in the patient’s best interests to receive the unlicensed treatment. Professor John Collinge, the Director of the MRC Prion Unit at UCL, who led the development of the PRN100 treatment, said, ‘’The treatment is an artificially manufactured antibody, which has been created in the laboratory. The antibody has been designed to bind tightly to normal proteins in the brain.

The aim is to prevent abnormal prions from being able to attach themselves to healthy proteins, meaning that they can not grow and cause devastation throughout the brain. As this is the first time this treatment has been used in humans we can not predict what the outcome will be but laboratory testing has shown the potential to treat prion infection. A key issue will be whether a sufficient quantity of the drug is able to cross the blood brain barrier to reach the brain tissue, where it needs to work.

We will proceed with extreme caution in very tightly controlled conditions. A team of experts from a range of disciplines will make collective decisions in the best interests of the patient.”

The patient and their family expressed their wish to receive this treatment and supported the UCLH NHS Foundation Trust’s court application. UCLH’s Chief Executive Professor Marcel Levi said, “Creutzfeldt-Jakob Disease:CJD is a rare and cruel disease, which rapidly destroys the brain, affecting memory, thinking, speech, balance, movement and behaviour.

There is currently no cure or treatment for CJD. At present, caring for patients with CJD involves trying to use medicines to alleviate symptoms only but sadly, the disease always results in the rapid death of the patient. The court’s confirmation today is an important step forward in tackling this devastating illness.”

Sporadic CJD, the most common form of the disease in humans, is caused, when healthy proteins, which exist normally in the human body become spontaneously misshapen and build up in the brain. These misshapen proteins, which are called prions, stick to other healthy proteins causing them to become misshapen too and the disease spreads through the brain.

Our immune system produces antibodies to fight infections, which invade the body. However, as abnormal prions are made of one of the body’s own proteins, our immune system does not make antibodies to fight them. The patient will initially receive the treatment by a drip into a vein in the arm. They will be monitored around the clock by a team of experts from UCLH.

The hospital team are preparing for a range of possible outcomes, including, the treatment having no measurable effect and the treatment slowing or halting the progression of the disease. The treatment is not expected to reverse any brain damage, that has already occurred.

The patient, may, also, experience side effects, which could lead the clinical team to limit or halt the doses of the treatment given.

In order to provide this treatment to a patient, UCLH created an oversight group, independent of the MRC Prion Unit and treating clinicians. The group is comprisesd with world-leading experts from a range of disciplines and it has met regularly with lawyers and patient advocates from the charity Cure CJD Campaign. The group considered the numerous and complex clinical, safety, legal and ethical issues arising from the potential use of this unlicensed treatment for CJD.

UCLH will await the response of the first patient to this treatment before considering a second patient.:::ω.

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Regine Humanics Foundation Begins Its Journey Today: The Humanion Is Now A Regine Humanics Foundation Publication

 
 

|| April 06: 2018 || ά. The Humanion was first published on September 24, 2015 and has been run, since that day, on a complete voluntary basis without any 'formal' or 'constituted' manner or form and, it was run on as a Human Enterprise, which is an idea of Humanics, in which, ownership is replaced by belongingship and, thus, in a Humanical Society, no one owns anything but everyone belongs to the whole as the whole belongs to everyone lawfully and equally and, it neither believes in nor makes money but human utilities, needs, aspirations, creativity, imagination and dreams are served without money, where everyone works and creates for all others as all others create and work for all others, thus, bringing in meaning and purpose to life along with it come natural justice, equality and liberty, that establish a true civilisation within the Rule of Law. And in one word, this system of human affairs management is called, Humanics and a society that runs itself in humanics is called a humanical society. Today, we have begun the process of 'constituting' this Human Enterprise, which does not exist in the current system, but the next closest thing to it, that exists in the UK Law is Social Enterprise. Therefore, today, Friday, April 06, 2018, we are beginning Regine Humanics Foundation, that is the 'Agency', that will lead, run, manage and develop everything, that The Humanion has been trying to do.

Regine Humanics Foundation is established by the Thinker, Author, Poet, Novelist, Playwright, Editor of The Humanion, Festival Director of London Poetry Festival and a Humanicsxian: hu: maa: neek: tian: One, that believes in, lives and exists by Humanics, Mr Munayem Mayenin, of London, England, United Kingdom. Mr Mayenin says, ''Humanics is a vision; people, may, call it, utopia, we, call it our Humanicsovicsopia; Humanics. Humanics is our philosophy, our faith, our conviction, our resolution, our way of existing, thinking, being and doing: to seek and try to do so in the determination that all we must do and be is to exist to advance the human condition. People, readers and agencies and organisations, from all across England, Scotland, Northern Ireland, Wales and the whole of the United Kingdom and Australasia, Africa, Asia, Europe, North and South America, from all walks and strata of life, have supported our endeavours, supported The Humanion and The Humanion Team, who volunteered their time to run things, since the beginning of The Humanion and long before that, when other things, that are now part of The Foundation, were developing. Nothing has changed in terms of the nature and value of what we have been seeking to do.''

''But the founding of The Foundation brings it all in a solid foundation so that we can keep on building this 'vision' so that it keeps on going regardless of who come to take the vision-mission of The Foundation forward. The Foundation runs along with time and along with the flowing humanity. This is the dream, this is the vision, this the hope in founding this Foundation. And, in this, we hope and invite all our readers, supporters, well wishers and all agencies and organisations to support our endeavours to build something, a Human Enterprise, which we are in the process of registering as a Social Enterprise, as a Community Interest Company, working for the common good of the one and common humanity. No one makes or takes profit out of The Foundation, which now runs The Humanion and everything else, that is part of it. The Foundation, once registered, will have an Asset Lock, which means that in any event, should The Foundation dissolve itself, all its existing assets shall go to a similar Social Enterprise. Therefore, we invite everyone to support The Foundation, support The Humanion in whatever way they can. And, there are endless number of ways people and organisations can support The Foundation and The Humanion.'' ::: ω.

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Beauroblubellogenics: And Will You Not Sing For The Beautiful Blue Belle

 

|| April 06: 2018 || ά.  On September 24, 2017, reporting the piece, published here, again, The Humanion wrote: ''And, despite the 'progress' Medicine has made over millennia, since the days of Hippocrates, the Blood Brain Barrier remains, as it has always been, an impenetrable, impregnable 'enigma'. And this calls on for us to show respect, regard and humility to Mother's Nature's greatest of all works, to, what The Humanion terms as, The Architectonics and The Mechanoprincipium'. The Researcher, in this story, Dr Zaynah Maherally, puts it beautifully, ''It is a dynamic structural, physiological and biochemical fortification that, in essence, protects the brain by providing multiple layers of armour, stopping molecules from entering the brain. It’s highly selective in what it allows past'.

We need to seek to go through it, this impenetrable barrier, yes, but it is there for the absolute necessity and a great deal of it, about most of it, we do not have a comprehension. Therefore, we publish this piece, which is great news, but we hope that more researchers in neurosciences would venture into the field of Blood Brain  Barrier Research, for in itself, it holds the potential to be larger a science than neurology itself. And, as and when, this branch of neurology, develops its own course, in a few hundred years, let them consult this piece, that had proposed its 'prospect-existence and given it a name. The Beautiful Blue Belle in poetic term and in scientific, Beauroblubellogenics: the neuro-science branch, that does nothing but studies the Blood Brain Barrier. Therefore, here, this is for Beauroblubellogenics for the Beautiful Blue Belle, the Blood Brain Barrier. Dear Reader, you, may not, have read these terms and heard of the ideas and concepts they represent, but they have been published and are part of the printed world.''

The printed world existed in 'imagination' and in living that imagination in learning and creating, which, then, became creative and scientific works, that, then, got into print, in which the ideas of the Beautiful Blue Belle was elaborated as part of the celebration of this astonishing 'mechanism' of the Blood Brain Barrier and, from there, arises Beauroblubellogenics. Here, The Humanion, presents Beauroblubellogenics, the science of studying the Blood Brain Barriers: We envision that the people, who are to take forward this discipline, are not only qualified Neurologists but are practising at the Most Senior Consultant Level and they are such minds, who have developed 'the equi-competence' in that same Most Senior Consultant-Level in all the major branches of Medicine so that not only have they the knowledge, expertise, insight, experience and study in them but, also, they have developed both a 'Nano-seismic' and 'Universal' views of Medicine, in between which views there exist myriad of other views, such as, atomic, anatomic, molecular, genetic, biochemical, neurological, genetics etc, as well as, a Philosophy of Medicine. In other words, these are the minds, that can, only, be described as 'Living Encyclopaedic Minds'. ::: ω.

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For Beauroblubellogenics for the Beautiful Blue Bell: The Blood Brain Barrier: New Model May Help Overcome Its Impenetrable Fortress

 

|| April 06: 2018: University of Portsmouth News || ά.   Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier. The brain is protected by the near-impermeable blood brain barrier, a fortress, which protects the brain but which, also, prevents the treatment of brain diseases, including, brain tumours. And, despite the 'progress' Medicine has made over millennia, since the days of Hippocrates, the Blood Brain Barrier remains, as it has always been, an impenetrable, impregnable 'enigma'. And this calls on for us to show respect, regard and humility to Mother's Nature's greatest of all works, to the, what The Humanion terms as, The Architectonics and The Mechanoprincipium'. The Researcher, in this story, Dr Zaynah Maherally, puts it beautifully, ''It is a dynamic structural, physiological and biochemical fortification that, in essence, protects the brain by providing multiple layers of armour, stopping molecules from entering the brain. It’s highly selective in what it allows past.''

We need to seek to go through it, this impenetrable barrier, yes, but it is there for the absolute necessity and a great deal of it, about most of it, we do not have a comprehension. Therefore, we publish this piece, which is great news, but we hope that more researchers in neurosciences would venture into the field of Blood Brain  Barrier Research, for in itself, it holds the potential to be larger a science than neurology itself. And, as and when, this branch of neurology, develops its own course, in a few hundred years, let them consult this piece, that had proposed its 'prospect-existence and given it a name. The Beautiful Blue Belle in poetic term, and in scientific, Beauroblubellogenics: the neuro-science branch, that does nothing but studies the Blood Brain Barrier. Therefore, here, this is for Beauroblubellogenics for the Beautiful Blue Bell, the Blood Brain Barrier. Dear Reader, you, may not, have read these terms and heard of the ideas and concepts they represent, but they have been published and are part of the printed world. 

Dr Zaynah Maherally and the research team at the University of Portsmouth have developed a model, that mimics the blood brain barrier, which could pave the way for better, more efficient and reliable tests of drugs to treat brain diseases. The model, the result of slow painstaking research started in 2007, is published in the FASEB Journal. Dr Maherally said, “The blood brain barrier is strikingly complex and notoriously difficult for scientists to breach. Its role, to protect the brain, makes it difficult for most drugs to make their way into the brain to treat brain tumours.

In a person with a brain disease like a brain tumour or other neurological conditions, such as, Parkinson’s Disease, Dementia or head injuries, the strikingly complex defence works against medics and scientists trying to deliver what could be life-saving or life-prolonging treatments.”

A common way medics currently gain access to the brain is by using a pump to deliver drugs into the brain using a catheter, bypassing the blood brain barrier. The researchers’ major goal was to develop a three-D all-human reproducible and reliable model of the blood brain barrier using human cells in order to better simulate the human blood brain barrier for the study of diseases and treatments.

Many researchers use non-human animal cells to build blood brain barrier models with which to explore brain cancer and deliver drugs to the brain. Animal models have been relied upon until now as there wasn’t a reliable alternative and accessing human tissue for research can be difficult.

Professor Geoff Pilkington, who leads the research group at Portsmouth, is delighted at the progress that’s been made in modelling the blood brain barrier, a holy grail in the study of brain diseases. Professor Pilkington said, “This is the first real, three-D, all-human blood brain barrier model and it’s hugely significant in our field.

''Research will now widen to better understand how cancers metastasise from breast and lung to the brain, as well as, evaluating nano-particle drug delivery and making opportunities to create temporary openings in the barrier to allow drugs to pass through into the brain.

Dr Maherally said, “It’s taken several years to get to this stage and we believe this model will significantly reduce the number of animals used in such studies and reduce the time it takes to get a promising therapeutic into clinical trials.”

The research was funded by Animal Free Research UK, previously known as Dr Hadwen Trust, and is supported by the charity Brain Tumour Research.

This was, originally, published, in Neurology on || September 24: 2017: University of Portsmouth News || ::: ω.

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Blood Is The Fountain Of The Heart Of Life: Conducted By The Heart: Played By The Orchestral Work Of The Ever-Efficient Kapillarika-Run: The Blood Is The Water: The Plasma: The White Cells: The Red Cells: The Platelets: The Haemoglobin: The Oxygen And The Nutrients And Minerals: The Flow: The Motion: The Rhythm: The Pulse: The Systolic: The Diastolic: The Law: The Glow: The Sparkle: The Current: The Concurrent: The Gradient: The Movement: The Rule Of Law: Blood Is The Victorian Lantern-Illuminator Of The Fire Of Life: Blood Running Is The Proof That Life Is Going And That: Despite All The Obnoxious People Seeking To Divide Humanity: Blood Offers The Science: That Humanity IS ONE: The Humanion

 

 

 

 

 

 

 

Life's Laurel Is You In One-Line-Poetry A Heaven-Bound Propagated Ray Of Light Off The Eye Of The Book Of Life: Love For You Are Only Once

 

 

Life: You Are The Law The Flow The Glow: In Joys In Hurts You Are The Vine-Songs On The Light-Trellis

 

 

 

 

   
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

|| All copyrights @ The Humanion: London: England: United Kingdom || Contact: The Humanion: editor at thehumanion.com || Regine Humanics Foundation Ltd: reginehumanics at reginehumanicsfoundation.com || Editor: Munayem Mayenin || First Published: September 24: 2015 ||
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