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The Arkive
|| Year Delta: London: Saturday: January 19: 2019: We Keep On Walking On The Path of Humanics ||
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I Humanics Spring Festival 2019: April 06 in London

I Regine Humanics Annual Lecture 2019: Whither to Homo Sapiens: Delivered by Dr J Everet Green: April 06 in London

VII London Poetry Festival 2019: St Matthews at Elephant and Castle: Meadow Row: London SE1 6RG: October 14-15

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Regine Humanics Foundation Ltd Publishes The Humanion among doing other things: We do not and shall not accept fundings or contributions from any type, form, manner and layer of Governments of national, international, supra-national or any other type or bodies formed by them nor from rich individuals or bodies or agencies of any kind. This, to us, is as a matter of absolute philosophic principle to ensure our resolute and complete independence. The ways, in which, we invite support from the readers, members of the public and all other individuals and agencies and businesses of any kind, are: a: Voluntary Subscription Payments: b: Voluntary Contributions: c: The Minimal and Symbolic Membership Fees to Our Regineumanics Family: d: Buying a Copy of The Long Walk to Humanics: e: Contributing to Our Events and f: Advertisement in The Humanion. We say it here and invite you for your support and we do not keep asking you on every page your visit to read the materials. You make a conscious, wilful and philosophic choice to Support The Humanion and The Foundation. If, you do: thank you: If, you do not, thank you, too, for reading The Humanion. The world has, apparently, accepted that Capitalism is the High Pinnacle of All Systems and, some still dream that Marxism will rescue humanity from this Killing Mechanism Capitalism, we refuse to subscribe to that and Humanics is the Post-Marxist and Post-Capitalistic World View of What Humanity can be and what it can do and how infinitely better a human condition can be created in a Humanical Society, by eradicating ownership and money and by establishing belongingship in human enterprise, setting all humans at liberty and equality under the rule of law in natural justice with a direct form of democracy, humanics calls it, Humanicsovics, in which, each human soul is her:his own High Representative. In this, Humanics is the Minority Vision and, in this, we do not and can not expect millions and billions of people supporting our vision today but We Whole-Heartedly Believe That ONE DAY This Humanity Shall BE ALL HUMANICAL: By When: We Know Not But This: That Being a Monstrous Killing Mechanism Capitalism IS Unsustainable: But the World Shall Change One Day and Every Change Begins with an Idea, with a Vision: We invite you to Envision the Vision of Humanics and Support The Humanion and The Foundation to Keep Taking Forward the Vision of Humanics for an Infinitely Better Humanity in an Infinitely Better Human Condition for All Humanity Across Mother Earth. Thank You.

First Published: September 24: 2015
The Humanion



The Humanion UK Online Daily


As the Mother Earth Belongs to Every Single Human Being of the Humanion Regine Humanics Foundation Ltd and The Humanion Belong to All for We are a Human Enterprise: A Not for Profit Social Enterprise: Support Your Daily Quality Newspaper and Let Us Build an Institution That Will Flow with Time with the Rainbow Peoples of This Earth Far Into the Flowing Future: Support The Humanion: Support Regine Humanics Foundation


























What Does Not Die











In Hampshire in an autumn wood the squirrel I found that came to say hello
In New Hampshire life’s voices went rippling human joys and sorrows and
In Union Square I saw the sun painting the green leaves with photon-paints
Allwhere life is a song written and sung in many a form in many a rainbow
A rainbow it is always allwhere marking the same shape of life-expressions

It is always in units of atoms
Units of photons and of cells
DNAs RNAs and neurons
Always the same rises ee falls
Always it is the song of cells

And the Empire State Building raised a spectacle in Manhattan skyline as
The traffic lit the air in all its expressions in the evening and in Scotland I
Saw heather and hyacinth in Swansea the light and its spread the same
Light the same song written and sung in many a form in many a rainbow
And it is the same that drives us to strive to stretch to reach to risk to rise

It is always magnetic
Always electric and
Chemical and active
Biochemical it is as
It shapes the cell-rise

I saw grace in human faces in Prague in Granada in Dhaka in Rome or in
London Manchester or York and found moss on city brick walls and saw
Butterflies on squeezed in greens of tiny spaces in town gardens and saw
Waters mining for life poetry in silence music in the ferns climbing onto
The trellis of light heard seagulls’ cries as human babies in all-everyday

In everyday momentary miracles
I saw life’s rainbow biochemistry
Unfolding noughts in paperboats
It is always the same song of love
That never dies and forever lives

:Munayem Mayenin: November 07: 2015

DNA Origami: A Precise Measuring Tool for the Optimal Antibody Effectiveness



|| January 17: 2019: Karolinska Institutet News || ά. Using DNA origami, a DNA-based design of precise nano-structures, scientists at Karolinska Institutet in collaboration with researchers at the University of Oslo, have been able to demonstrate the most accurate distance among densely packed antigens in order to get the strongest bond to antibodies in the immune system. The study, which is published in the journal Nature Nanotechnology, may be, of significance to the development of vaccines and immunotherapy used in cancer.

Vaccines work by training the immune system with harmless mixtures of antigens, foreign substances, that trigger a reaction in the immune system, from a virus, for example. When the body is then exposed to the virus, the immune system recognises the antigens, that the virus carries and is able to effectively prevent an infection. Today, many new vaccines make use of something, called, ‘particle display’, which means that the antigens are introduced into the body, presented to the immune system in the form of particles with lots of antigens densely packed on the surface.

Particle display of antigens works in some cases better as a vaccine than, simply, providing free antigens and one example is the HPV vaccine, which protects against cervical cancer. Antibodies or immunoglobulins, perhaps, are the most important part of the body's defence against infection, bind antigens very effectively. The antibodies have a Y-shaped structure where each ‘arm’ can bind an antigen. In this way, each antibody molecule can usually bind two antigen molecules.

In the current study, the researchers examined how closely and how far apart from each other the antigens can be packed without significantly affecting the ability of an antibody to bind both molecules simultaneously. "We have, for the first time, been able to, accurately, measure the distances between antigens, that result in the best simultaneous binding of both arms of different antibodies. Distances of, approximately, 16 nano-metres, provide the strongest bond.” says Professor Björn Högberg, at the Department of Medical Biochemistry and Bio-physics, Karolinska Institutet, who led the study.

The study, also, shows that immunoglobulin M:IgM, the first antibody involved in an infection, has, significantly, larger reach, that is the ability to bind two antigens, than previously thought. IgM, also, has a, significantly, greater reach than the IgG antibodies produced at a later stage of an infection. 

The technology the scientists used is based on a relatively new technique, known as, DNA origami, which has been in use since 2006, that allows precise nano-structures to be designed using DNA. However, it is, only, in recent years that scientists have learned to use this technique in biological research. The application used in the study is newly developed.

"By putting antigens on these DNA origami structures, we can manufacture surfaces with precise distances between the antigens and, then, measure how different types of antibodies bind to them. Now, we can measure, exactly, how antibodies interact with several antigens in a manner, that was previously impossible.” says Professor Björn Högberg.

The results can be used to better understand the immune response, for example, why B lymphocytes, a type of white blood cell, are so effectively activated by particle display vaccines and to design better antibodies for immunotherapy when treating cancer.

The research has been conducted in close collaboration with the Laboratory of adaptive immunity and homeostasis led by Mr Jan Terje Anderson, at the University of Oslo and Oslo University Hospital.

“We study the relationship between the structure and function of antibodies. Such insight is important when we design the next generation of vaccines and antibodies for tailor-made treatment of serious diseases. We have long been looking for new methods, that can help us get detailed insight into how different antibodies bind to the antigens. The collaboration with Björn Högberg has opened completely new doors.” says Mr Jan Terje Andersen.

The study was funded by the Swedish Research Council, the Swedish Foundation for Strategic Research, the Knut and Alice Wallenberg Foundation, the StratRegen:Karolinska Institutet and the Research Council of Norway.

The Paper: Binding to Nano-patterned antigens is Dominated by the Spatial Tolerance of antibodies: Alan Shaw, Ian T Hoffecker, Ioanna Smyrlaki, Joao Rosa, Algridas Grevys, Diane Bratlie, Inger Sandlie, Terje Enar Michaelsen, Jan Terje Andersen and Björn Högberg: Nature Nano-technology: Online 14 January 14: 2019:::ω.

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Here Is the Human Cell Recycling Centre: New Research Finds and Presents Its Potential




|| December 17: 2018: University of Dundee News || ά. A previously undiscovered stress signal can kick-start a human cell’s ‘recycling centre’, University of Dundee scientists have discovered. A team researchers from the University’s School of Life Sciences has found that signals sent to a protein, known as, STAT3, will trigger the production of lysosomal enzymes, which are crucial to breaking down proteins in the human body, an essential process in keeping cells healthy. The findings of the Wellcome Trust-funded study, published today in Nature Communications, may, pave the way for research in to several neuro-degenerative diseases.

Professor Colin Watts, Emeritus Professor in the Division of Cell Signalling and Immunology, said, “Virtually, all cells have specialised structures, called, lysosomes. These have emerged as multi-functional sites, that generate information in the immune system, act as nutrient sensing signalling platforms and serve as recycling centres. Lysosomes are filled with enzymes, that can break down proteins and other molecules for recycling but how cells boosted their lysosome capacity, when a greater demand was placed on them was not fully understood.” The study’s Lead Author, Dr Jonathan Martinez-Fabregas, discovered that, when lysosomal capacity is insufficient, a stress signal is sent from the interior of the lysosome to a protein, called, STAT3. When activated, STAT3 enters the cell nucleus and drives the production of more lysosomal enzymes.

Under normal conditions this clears any backlog but, if, a key enzyme is missing, as occurs in several so-called lysosomal storage diseases, such as, Tay-Sachs Disease, material can begin to accumulate within the body. The study found that, when the cells in the kidney responsible for protein recycling are overloaded, the stress signal is generated but when a key enzyme is lacking, the backlog can not be shifted and the kidney starts to fail.

Dr Martinez-Fabregas, said, “Another signalling system, known as, the TFEB system, had been described to regulate lysosome capacity but, this seemed to operate, mainly, under conditions of cellular starvation, when cells begin to auto digest because of nutrient deprivation.

Discovering this second pathway, controlled by STAT3, to boost lysosomal capacity makes complete sense. The endpoint is similar but the triggers and the signalling pathways are very different.”

Professor Watts said, “These results are potentially important as there is a growing interest in manipulating the lysosomal system to try to alleviate lysosomal storage diseases and, additionally, to try to clear the protein aggregates, that, may, contribute to neuro-degenerative disease. Those efforts have, understandably, been focussed on the TFEB system but our results reveal an additional control point, that could, potentially, be utilised.”:::ω.

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For Stories Published in Biochemistry in Year Gamma Arkive


|| April 06: 2018 || ά. The Humanion was first published on September 24, 2015 and has been run, since that day, on a complete voluntary basis without any 'formal' or 'constituted' manner or form and, it was run on as a Human Enterprise, which is an idea of Humanics, in which, ownership is replaced by belongingship and, thus, in a Humanical Society, no one owns anything but everyone belongs to the whole as the whole belongs to everyone lawfully and equally and, it neither believes in nor makes money but human utilities, needs, aspirations, creativity, imagination and dreams are served without money, where everyone works and creates for all others as all others create and work for all others, thus, bringing in meaning and purpose to life along with it come natural justice, equality and liberty, that establish a true civilisation within the Rule of Law. And in one word, this system of human affairs management is called, Humanics and a society that runs itself in humanics is called a humanical society. Today, we have begun the process of 'constituting' this Human Enterprise, which does not exist in the current system, but the next closest thing to it, that exists in the UK Law is Social Enterprise. Therefore, today, Friday, April 06, 2018, we are beginning Regine Humanics Foundation, that is the 'Agency', that will lead, run, manage and develop everything, that The Humanion has been trying to do.

Regine Humanics Foundation is established by the Thinker, Author, Poet, Novelist, Playwright, Editor of The Humanion, Festival Director of London Poetry Festival and a Humanicsxian: hu: maa: neek: tian: One, that believes in, lives and exists by Humanics, Mr Munayem Mayenin, of London, England, United Kingdom. Mr Mayenin says, ''Humanics is a vision; people, may, call it, utopia, we, call it our Humanicsovicsopia; Humanics. Humanics is our philosophy, our faith, our conviction, our resolution, our way of existing, thinking, being and doing: to seek and try to do so in the determination that all we must do and be is to exist to advance the human condition. People, readers and agencies and organisations, from all across England, Scotland, Northern Ireland, Wales and the whole of the United Kingdom and Australasia, Africa, Asia, Europe, North and South America, from all walks and strata of life, have supported our endeavours, supported The Humanion and The Humanion Team, who volunteered their time to run things, since the beginning of The Humanion and long before that, when other things, that are now part of The Foundation, were developing. Nothing has changed in terms of the nature and value of what we have been seeking to do.''

''But the founding of The Foundation brings it all in a solid foundation so that we can keep on building this 'vision' so that it keeps on going regardless of who come to take the vision-mission of The Foundation forward. The Foundation runs along with time and along with the flowing humanity. This is the dream, this is the vision, this the hope in founding this Foundation. And, in this, we hope and invite all our readers, supporters, well wishers and all agencies and organisations to support our endeavours to build something, a Human Enterprise, which we are in the process of registering as a Social Enterprise, as a Community Interest Company, working for the common good of the one and common humanity. No one makes or takes profit out of The Foundation, which now runs The Humanion and everything else, that is part of it. The Foundation, once registered, will have an Asset Lock, which means that in any event, should The Foundation dissolve itself, all its existing assets shall go to a similar Social Enterprise. Therefore, we invite everyone to support The Foundation, support The Humanion in whatever way they can. And, there are endless number of ways people and organisations can support The Foundation and The Humanion.'' ::: ω.

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Charing Cross Hospital: Please, Note, The CCH Clock Does Work Perfectly


















University College Hospital London















Eastman Dental Hospital















Life's Laurel Is You In One-Line-Poetry A Heaven-Bound Propagated Ray Of Light Off The Eye Of The Book Of Life: Love For You Are Only Once



Life: You Are The Law The Flow The Glow: In Joys In Hurts You Are The Vine-Songs On The Light-Trellis


























|| All copyrights @ The Humanion: London: England: United Kingdom || Contact: The Humanion: editor at || Regine Humanics Foundation Ltd: reginehumanics at || Editor: Munayem Mayenin || First Published: September 24: 2015 ||
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